- The second semi-final was held on 22 May 2008
- The United Kingdom, France and Serbia voted in this semi-final.
| Draw | Country | Language | Artist | Song | Place | Points |
|---|---|---|---|---|---|---|
| 01 | Iceland | English | Euroband | “This Is My Life” | 8 | 68 |
| 02 | Sweden | English | Charlotte Perrelli | “Hero” | 12 | 54 |
| 03 | Turkey | Turkish | Mor ve Ötesi | “Deli” | 7 | 85 |
| 04 | Ukraine | English | Ani Lorak | “Shady Lady” | 1 | 152 |
| 05 | Lithuania | English | Jeronimas Milius | “Nomads in the Night” | 16 | 30 |
| 06 | Albania | Albanian | Olta Boka | “Zemrën e lamë peng” | 9 | 67 |
| 07 | Switzerland | Italian | Paolo Meneguzzi | “Era stupendo” | 13 | 47 |
| 08 | Czech Republic | English | Tereza Kerndlová | “Have Some Fun” | 18 | 9 |
| 09 | Belarus | English [B] | Ruslan Alekhno | “Hasta la Vista” | 17 | 27 |
| 10 | Latvia | English | Pirates of the Sea | “Wolves of the Sea” | 6 | 86 |
| 11 | Croatia | Croatian | Kraljevi ulice and 75 cents | “Romanca” | 4 | 112 |
| 12 | Bulgaria | English | Deep Zone and Balthazar | “DJ, Take Me Away” | 11 | 56 |
| 13 | Denmark | English | Simon Mathew | “All Night Long” | 3 | 112 |
| 14 | Georgia | English | Diana Gurtskaya | “Peace Will Come” | 5 | 107 |
| 15 | Hungary | English, Hungarian | Csézy | “Candlelight” | 19 | 6 |
| 16 | Malta | English [C] | Morena | “Vodka” | 14 | 38 |
| 17 | Cyprus | Greek | Evdokia Kadi | “Femme Fatale” | 15 | 36 |
| 18 | Macedonia | English | Tamara, Vrčak & Adrian | “Let Me Love You” | 10 | 64 |
| 19 | Portugal | Portuguese | Vânia Fernandes | “Senhora do mar (Negras águas)” | 2 | 120 |